Table 6.
Top Nonsynonymous Variant Identified in PTPRO Is Also Significantly Associated with Obstruction and Emphysema in a Larger Cohort
| rs61754411 Genotype | n | Age (yr) [Median (IQR)] | Females (%) | Smoking History (Pack-Years) [Mean (IQR)] | F-950 [Mean (IQR)] | FEV1 (% Predicted) [Mean (IQR)] |
|---|---|---|---|---|---|---|
| CC | 652 | 64 (60–69) | 46.6 | 54.8 (30–60) | 0.076 (0.004–0.096) | 0.692 (0.403–0.931) |
| CG | 34 | 64 (59–66) | 41.2 | 56.1 (35–70) | 0.126 (0.010–0.216) | 0.542 (0.232–0.828) |
| P value* | 0.217 | 0.539 | 0.843 | 0.035 | 0.009 |
Definition of abbreviations: F-950 = Hounsfield units value less than −950; IQR = interquartile range; PTPRO = protein tyrosine phosphatase, type O.
*
Two-tailed Student’s t test.