Table 3.
Baseline Demographic, MRI, and Right Heart Catheterization Data
| Demographics | All Patients (n = 576) | Incident Patients (n = 398) | Prevalent Patients (n = 178) | P Value | N |
|---|---|---|---|---|---|
| Age, yr | 57 (16) | 60 (15) | 52 (17) | <0.0001 | 576 |
| Sex M/F, n (male %) | 182/394 (46) | 132/266 (50) | 50/128 (39) | 0.223 | 576 |
| WHO functional class, n | |||||
| I | 5 | 2 | 3 | ||
| II | 50 | 32 | 17 | ||
| III | 451 | 308 | 141 | ||
| IV | 70 | 56 | 14 | ||
| Subgroup, n | |||||
| IPAH | 260 | 179 | 80 | 0.946 | |
| CTD | 195 | 147 | 48 | 0.022 | |
| Congenital | 63 | 31 | 32 | <0.0001 | |
| Other (portal, HIV, and drugs) | 58 | 41 | 18 | 0.883 | |
| PAH therapy, n | |||||
| Monotherapy oral | 155 | 126 | 29 | <0.0001 | 576 |
| Combination oral | 308 | 205 | 104 | 0.138 | 576 |
| Prostanoid | 107 | 62 | 45 | 0.005 | 576 |
| RHC |
|||||
| mPAP, mm Hg | 48 (13) | 48 (13) | 45 (14) | 0.090 | 447 |
| mRAP, mm Hg | 10 (6) | 10 (3) | 10 (5) | 0.369 | 443 |
| PAWP, mm Hg | 10 (3) | 10 (3) | 11 (3) | 0.046 | 440 |
| SO2, % | 64 (10) | 63 (9) | 67 (10) | 0.003 | 446 |
| CI, L/min/m2 | 2.8 (0.9) | 2.7 (0.8) | 3.3 (1.1) | <0.0001 | 446 |
| PVRI, Wood units · m2 | 16 (8.1) | 15.7 (7.9) | 14.0 (9.5) | 0.206 | 440 |
| Cardiac MR indices | |||||
| RVEDVI, ml/m2 | 94 (35) | 94 (33) | 94 (40) | 0.978 | 576 |
| RVEDVI %pred | 128 (47) | 129 (45) | 124 (52) | 0.233 | 576 |
| RVESVI, ml/m2 | 59 (29) | 62 (28) | 54 (30) | 0.005 | 576 |
| RVESVI %pred | 246 (125) | 262 (126) | 210 (117) | <0.0001 | 576 |
| RVEF % | 39 (14) | 36 (14) | 44 (13) | <0.0001 | 576 |
| RVEF %pred | 58 (22) | 54 (21) | 67 (20) | <0.0001 | 576 |
| RVSVI, ml/m2 | 35 (16) | 33 (14) | 40 (19) | <0.0001 | 576 |
| RVSVI %pred | 71 (33) | 67 (30) | 20 (19) | <0.0001 | 576 |
| LVEDVI, ml/m2 | 54 (19) | 50 (16) | 61 (23) | <0.0001 | 576 |
| LVEDVI %pred | 69 (24) | 66 (21) | 79 (30) | <0.0001 | 576 |
| LVESVI, ml/m2 | 18 (9) | 17 (8) | 20 (11) | 0.001 | 576 |
| LVESVI %pred | 73 (38) | 70 (35) | 79 (46) | 0.049 | 576 |
| LVEF % | 67 (11) | 66 (11) | 68 (9) | 0.036 | 576 |
| LVEF %pred | 98 (15) | 97 (16) | 101 (14) | 0.008 | 576 |
| LVSVI, ml/m2 | 26 (14) | 23 (12) | 12 (16) | <00001 | 576 |
| LVSVI %pred | 52 (28) | 47 (24) | 65 (32) | <0.0001 | 576 |
| RVEDMI | 35 (20) | 36 (20) | 34 (21) | 0.330 | 563 |
| RVEDMI %pred | 124 (70) | 127 (70) | 114 (70) | 0.120 | 563 |
| PA forward flow index, L/min/m2 | 3.2 (1.4) | 3.0 (1.3) | 3.6 (1.5) | <0.0001 | 556 |
| PA stiffness metrics | |||||
| PA relative area change | 12 (8) | 11 (7) | 14 (9) | <0.0001 | 557 |
| PA distensibility | 0.28 (0.31) | 0.25 (0.30) | 0.37 (0.31) | 0.003 | 447 |
| RV–PA coupling metrics | |||||
| Ea, mm Hg/ml/m2 | 2.0 (1.4) | 2.2 (1.4) | 1.4 (1.2) | <0.0001 | 442 |
| Ees, mm Hg/ml/m2 | 0.95 (0.246) | 0.9 (0.5) | 1.0 (0.5) | 0.024 | 447 |
| Ees/Ea ratio | 0.80 (0.83) | 0.7 (0.7) | 1.3 (1.2) | <0.0001 | 442 |
| MRI Ees/Ea ratio | 0.74 (0.47) | 0.7 (0.4) | 0.9 (0.5) | <0.0001 | 576 |
Definition of abbreviations: CI = cardiac index; CTD = connective tissue disease; Ea = arterial load; Ees = RV elastance; IPAH = idiopathic pulmonary arterial hypertension; LVEDVI = left ventricular end-diastolic volume index; LVEF = left ventricular ejection fraction; LVESVI = left ventricular end-systolic volume index; LVSVI = left ventricular stroke volume index; mPAP = mean pulmonary artery pressure; mRAP = mean right atrial pressure; MR = magnetic resonance; MRI = MR imaging; PA = pulmonary artery; PAH = pulmonary arterial hypertension; PAWP = pulmonary arterial wedge pressure; PVRI = pulmonary vascular resistance index; RHC = right heart catheterization; RV = right ventricular; RVEDMI = right ventricular end-diastolic mass index; RVEDVI = right ventricular end-diastolic volume index; RVEF = right ventricular ejection fraction; RVESVI = right ventricular end-systolic volume index; RVSVI = right ventricular stroke volume index; SO2 = mixed venous oxygen saturation; WHO = World Health Organization.
Values are presented as mean (SD) unless otherwise stated.