. 2017 Jul 21;4:52. doi: 10.3389/fmolb.2017.00052

Table 4.

Various strategies of combinational delivery of chemotherapeutics and CSC-specific agents.

S. no.	CSC source and marker	Drug delivery system and combined chemotherapeutics	Mechanism of CSCs depletion	References
1	Multiple myelomaJJN3 cells, CD138−CD34–	Cremophor® EL	Increased efficacy of conventional chemotherapy	Yang et al., 2014
	Multiple myelomaJJN3 cells, CD138−CD34–	Anti-ABCG2 and paclitaxel	Increased efficacy of conventional chemotherapy
2	Breast cancer, MCF-7 cells, CD44+/CD24–	PEG-b-PCL polymeric micelles	Simultaneous killing of CSCs and non-CSCs	Zhang Y. et al., 2012
	Breast cancer, MCF-7 cells, CD44+/CD24–	Salinomycin and paclitaxel	Simultaneous killing of CSCs and non-CSCs
3	Glioblastoma, U87 cells, etc., CD133+ and SSEA-1+	Liposome	Sensitization of glioblastoma to chemotherapy	Kim et al., 2014a
	Glioblastoma, U87 cells, etc., CD133+ and SSEA-1+	Wtp53 plasmid DNA and Temozolomide	Sensitization of glioblastoma to chemotherapy
4	Breast cancer, BT474 cells, etc., CD44+/CD24–	Nanoparticle consisting of PEG-PAC and PEG-PUC	Simultaneous killing of CSCs and non-CSCs	Ke et al., 2014
		Thioridazine and doxorubicin
5	Colon cancer, HT-29 cells, CD133+	Biodegradable lipid nano complex	Sensitization of CSCs to chemotherapy	Liu et al., 2009
		siMDR1 and paclitaxel
6.	Breast cancer, MDA-MB-231 cells, ALDH+	PEG-PLA nanoparticle	Increased therapeutic response of CSCs	Li S. Y. et al., 2015
	Breast cancer, MDA-MB-231 cells, ALDH+	Decitabine and doxorubicin
7.	Breast cancer, MCF-7 and MDA-MB-231 cells, CD44+/CD24–	Liposome	Simultaneous killing of CSCs and non-CSCs	Liu et al., 2008
	Breast cancer, MCF-7 and MDA-MB-231 cells, CD44+/CD24–	Vinorelbine and parthenolide	Simultaneous killing of CSCs and non-CSCs
8.	Breast cancer, MCF-7 cells, CD44+/CD24–	Hyaluronan modified mesoporous silica nanoparticle	Simultaneous killing of CSCs and non-CSCs	Wang et al., 2013
		8-hydroxyquinoline and docetaxel
9.	Gastric cancer, BGC-823 cells, CD44+	Elatinases-stimuli nanoparticles	miR-200c mediated inhibition of CSCs and restoration of drug sensitivity	Liu Q. et al., 2013
		miR-200c and docetaxel
10.	Breast cancer, MDA-MB-231 cells, ALDH+	PEG-PLA nanoparticle	Differentiation of CSCs and increase of chemosensitivity	Sun et al., 2015
	Breast cancer, MDA-MB-231 cells, ALDH+	All-trans-retinoic acid and doxorubicin	Differentiation of CSCs and increase of chemosensitivity
11.	Prostate cancer, PC-3 cells, etc., CD133+	HPMA copolymers	Simultaneous killing of CSCs and non-CSCs	Zhou et al., 2013
		Cyclopamine and docetaxel	Simultaneous killing of CSCs and non-CSCs