Table 2. Representative chemical series discovered in three tractability campaigns.

ND, not determined; MoA, mode of action.

The scaffold column represents the selected pharmacophore with areas of substitution indicated by R. All data are reported for the single exemplar shown. IC₅₀ values are reported as the average of two replicate experiments with s.d. values calculated using the n−1 method.

^*Minimum inhibitory concentration measured against S. aureus WCUH29 wild type or A. baumannii BM652 efflux strains for S. aureus or A. baumannii campaigns with a minimum of two independent experiments.

^†MIC unit is in μM and is determined against M. tuberculosis H37Rv.