Table 2. Changes in risk discrimination for the risk of incident cancer in men and women combined after addition of anthropometric indicators to the null model.
Null model |
BMI |
WC |
HC |
WHR |
BMI+WC+HC |
|||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Estimate | 95% CI | Estimate | 95% CI | Estimate | 95% CI | Estimate | 95% CI | Estimate | 95% CI | Estimate | 95% CI | |
Obesity-related cancersa | ||||||||||||
AIC | 15826.6 | 15823.6 | 15820.6 | 15823.7 | 15823.4 | 15823.1 | ||||||
C-index | 0.688 | 0.676–0.699 | 0.687 | 0.675–0.698 | 0.663 | 0.649–0.677 | 0.663 | 0.650–0.677 | 0.664 | 0.651–0.678 | 0.663 | 0.650–0.677 |
Colorectal cancer | ||||||||||||
AIC | 5678.8 | 5672.8 | 5670.2 | 5674.8 | 5674.0 | 5673.5 | ||||||
C-index | 0.688 | 0.667–0.709 | 0.689 | 0.668–0.711 | 0.680 | 0.655–0.704 | 0.679 | 0.655–0.704 | 0.681 | 0.657–0.706 | 0.681 | 0.656–0.705 |
Breast cancerb | ||||||||||||
AIC | 5031.2 | 5030.3 | 5031.9 | 5032.0 | 5033.1 | 5032.9 | ||||||
C-index | 0.824 | 0.813–0.836 | 0.823 | 0.812–0.835 | 0.801 | 0.787–0.815 | 0.802 | 0.788–0.816 | 0.803 | 0.789–0.817 | 0.801 | 0.787–0.815 |
Other obesity-related cancersc | ||||||||||||
AIC | 4780.7 | 4782.7 | 4781.4 | 4782.2 | 4777.0 | 4780.6 | ||||||
C-index | 0.588 | 0.561–0.615 | 0.587 | 0.559–0.614 | 0.605 | 0.573–0.637 | 0.605 | 0.574–0.637 | 0.612 | 0.581–0.643 | 0.618 | 0.587–0.648 |
Abbreviations: AIC=Akaike Information Criterion; BMI=body mass index; CI=confidence interval; HC=hip circumference; WC=waist circumference; WHR=waist-to-hip ratio.
Note: Null model included sex, age, daily smoking (never, former, current, and missing), average alcohol consumption (g/d), education (primary or less, more than primary but less than college, college or university, missing), vigorous physical activity (yes, no, and missing), recruitment year, and height.
First primary cancers of the breast (postmenopausal), colorectum, lower oesophagus, cardia stomach, liver, gallbladder, pancreas, endometrium, ovary, and kidney.
Women only.
Same as all obesity-related cancers but excluding first primary cancers of the breast and of the colorectum.