Table 2. Treatment-related adverse events occurring in two or more participants, and all grade 3/4 treatment-related adverse events.
|
Grades 1–2 |
Grades 3–4 |
|||
|---|---|---|---|---|
| Event | No. of patients | % | No. of patients | % |
|
Cardiorenal | ||||
| Oedema, facial | 3 | 12 | ||
| Oedema, limbs | 4 | 16 | ||
| Elevated creatinine | 2 | 8 | ||
| Hypertension | 16 | 64 | 2 | 8 |
| Hypomagnesaemia | 7 | 28 | ||
| Hyponatraemia | 2 | 8 | ||
| Proteinuria | 3 | 12 | ||
|
Constitutional | ||||
| Dehydration | 2 | 8 | ||
| Fatigue | 15 | 60 | 1 | 4 |
|
Dermatologic | ||||
| Dry skin | 3 | 12 | ||
| Finger or nail changes | 3 | 12 | ||
| Rash | 20 | 80 | 3 | 12 |
|
Gastrointestinal | ||||
| Anorexia | 9 | 36 | ||
| Constipation | 3 | 12 | ||
| Diarrhoea | 13 | 52 | 1 | 4 |
| Elevated liver function tests | 8 | 32 | 3 | 12 |
| Mucositis | 2 | 8 | ||
| Nausea or vomiting | 16 | 64 | 2 | 8 |
|
HEENT | ||||
| Blurry vision | 5 | 20 | ||
| Change in taste | 6 | 24 | ||
| Congestion or postnasal drip | 2 | 8 | ||
| Floaters | 2 | 8 | ||
|
Haematologic | ||||
| Anaemia | 3 | 12 | 1 | 4 |
| Bleeding or bruising | 7 | 28 | ||
| Neutropenia | 3 | 12 | ||
| Thrombocytopenia | 10 | 40 | 6 | 24 |
|
Neurological | ||||
| Amnesia | 1 | 4 | 1 | 4 |
| Dizziness | 2 | 8 | ||
| Dysgeusia | 2 | 8 | ||
| Headache | 2 | 8 | ||
| Posterior reversible encephalopathy syndrome (PRES) | 1 | 4 | 1 | 4 |
Abbreviation: HEENT=head, eyes, ears, nose, and throat.