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. 2017 Aug;362(2):327–337. doi: 10.1124/jpet.117.241927

Fig. 3.

Fig. 3.

Guinea pigs were sensitized with ovalbumin (Ova) and challenged with (A) Ova alone or (B) Ova + LPS or unsensitized guinea pigs challenged with LPS and treated with once-daily i.p. vehicle or dexamethasone (20 mg/kg). (A and B) Mean time courses for changes in sGaw. Histograms represent the maximum bronchoconstriction values recorded during the EAR (0–6 hours) and LAR (6–12 hours); mean changes in sGaw are expressed as mean ± S.E.M. percent change from baseline before Ova challenge. (C) Analysis of the time taken for the EAR to recover to 50% of peak bronchoconstriction values. (D) AUC analysis of sGaw values for 0–12 hours, 0–6 hours, and 6–12 hours post-Ova challenge; also shown are data for naïve guinea pigs challenged with LPS; (E) mean time courses for changes in sGaw for naïve guinea pigs treated with LPS; n = 6 to 7; *Significantly different from vehicle treatment, P < 0.05; **P < 0.01; ***P < 0.001; performed with one-way ANOVA followed by Dunnett’s post-test.