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. 2017 Aug;362(2):327–337. doi: 10.1124/jpet.117.241927

Fig. 5.

Fig. 5.

Responses of airways to nebulized histamine delivered in a plethysmograph (0.3 mM, 2 minutes) to guinea pigs (A and B) sensitized and challenged with Ova and treated with once-daily i.p. (A) vehicle or (B) dexamethasone (20 mg/kg); (C and D) sensitized and challenged with Ova + LPS treated with once-daily i.p. (C) vehicle or (D) dexamethasone (20 mg/kg); (E and F) challenged with LPS and treated with once-daily i.p. (E) vehicle or (F) dexamethasone, 20 mg/kg. Histograms represent the mean peak response to histamine before and after Ova, Ova + LPS, or LPS challenge. Mean changes in sGaw are expressed as mean ± S.E.M. percent change from baseline. A negative value represents a bronchoconstriction. n = 6 or 7. *Significantly different from vehicle treatment P < 0.05; **P < 0.01; ***P < 0.001; performed with a two-tailed t test.