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. 2017 Mar 17;11(7):1592–1601. doi: 10.1038/ismej.2017.31

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Copyright © 2017 The Author(s)

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Scheme of (a) the proposed pathway of MA catabolism in R. pomeroyi DSS-3 and related MRC bacteria and (b) genomic regions encompassing the genes (dmmDABC) encoding the Dmm in R. pomeroyi DSS-3 and (c) Methylocella silvestris BL2. (d) Candidatus Pelagibacter ubique HTCC1062 does not possess dmmDABC in its genome despite containing all other genes required for TMA, TMAO and MMA degradation. amtB, ammonia transporter; CH₂=H₄F, 5,10-methylene tetrahydrofolate; DmmA, DmmB, DmmC, DmmD, DMA monooxygenase subunit A, B, C or D; GMA, gamma-glutamylmethylamide; GmaS, gamma-glutamylmethylamide synthetase; MgdABCD, N-methylglutamate dehydrogenase; MgsABC, N-methylglutamate synthase; NMG, N-methylglutamate; Tdm, trimethylamine N-oxide demethylase; Tmm, trimethylamine monooxygenase; tmoP, TMAO permease; TmoXVW, adenosine triphosphate-dependent TMAO transporter.