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. 2017 May 19;24(7):1140–1141. doi: 10.1038/cdd.2017.75

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Replisome unloading is controlled by two pathways. (a) During DNA replication termination, the CRL2^LRR1 ubiquitin ligase and the p97 segregase trigger replisome unloading from chromatin. (b) An additional backup mechanism that depends on the p97 adaptor UBXN3 drives replisome unloading from mitotic chromatin. See text for details. For the sake of clarity, the different components of the replisome are not shown