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. 2017 Feb 20;38(6):835–847. doi: 10.1038/aps.2016.166

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Copyright © 2017 CPS and SIMM

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Evaluation of synergism between DOX and MMC in MDA-MB-231 cells. (A) Dose-response curve for the ability of cells to form colonies after treatment exposure of MMC and DOX, alone and in combination at DOX/MMC molar ratio of 1:0.7 (Drug: 0.0005–20 μmol/L) for 1 h. The [Drug] for DOX/MMC combination is represented by the concentration of DOX. Data are presented as mean±SEM. n=6. (B) Median effect plot for MMC and DOX, alone and in combination. D_m and m were calculated from x-intercept and slope, respectively. (C) Combination index (CI) analysis of the interaction of MMC and DOX.