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. 2017 Jul 20;14:27. doi: 10.1186/s12989-017-0208-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Identification of downstream targets of HBL-1 in the regulation of MWCNTs toxicity. a Effect of hbl-1 mutation on the expressions of some potential target genes in MWCNTs exposed nematodes. b Effect of tir-1 or sym-1 mutation or RNAi knockdown of lpr-4 on MWCNTs toxicity in inducing intestinal ROS production. Sixty nematodes were examined per treatment. c Effect of tir-1 or sym-1 mutation on MWCNTs toxicity in decreasing locomotion behavior. Sixty nematodes were examined per treatment. Prolonged exposure was performed from L1-larvae to young adults. Exposure concentration of MWCNTs was 10 μg/L. Bars represent means ± SD. ^** P < 0.01 vs wild-type (if not specially indicated)