Skip to main content
. 2017 Jul 21;17:494. doi: 10.1186/s12885-017-3458-3

Table 2.

General dose reduction guidelines

Grade I Continue study treatment at same dose; monitor and treat as clinically indicated.
Grade II Continue study treatment at same dose; monitor and treat as clinically indicated.
Grade III Step 1. Interrupt study drug until toxicity reduced to ≤Grade 1.
Step 2. Restart study treatment at same dose or lower dose at discretion of investigator
Grade IV Step 1. Interrupt study drug until toxicity reduced to ≤Grade 2.
Step 2. Restart study treatment at lower dose level.