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. 2017 Jun 21;6(6):e52. doi: 10.1038/emi.2017.36

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Bornavirus encephalitis in horses. (A) Severe nonpurulent encephalitis with perivascular cuffing (asterisk) and microgliosis. Bar=250 μm. (B and C) Eosinophilic intranuclear inclusion bodies (arrows) in a brainstem neuron (B) and a trigeminal ganglion neuron surrounded by lymphohistiocytic infiltration (C). Bars=25 μm. (D and E) Immunohistochemical demonstration of BoDV antigen (brown signals) in neurons and glial cells and their processes. Bars=100 μm. (A–C) Hematoxylin and Eosin staining. (D and E) Bo-18 immunohistochemistry.