Skip to main content
. 2017 Jun 21;6(6):e59. doi: 10.1038/emi.2017.46

Figure 1.

Figure 1

Anti-HIV-1 molecules tested in the present study. (A) Schematic view of the gp120-targeting proteins 2Dm2m and 4Dm2m. (B) The targeting sites of the HIV-1 attachment inhibitors (2Dm2m and 4Dm2m) and the HIV fusion inhibitors (T20, T2635 and SFT). The CD4-binding site, CD4bs; the co-receptor binding site, CoRbs; an engineered single human CD4 domain targeting CD4bs in gp120, mD1.22; a potent neutralizing monoclonal antibody targeting CoRbs in gp120, m36.4; sifuvirtide, SFT. (C) Schematic view of the HIV-1 gp41 molecule and interactions between the CHR and NHR domains, as well as the CHR-derived fusion inhibitory peptides.