Table 2. Enhancement of the viral inactivation activity of the gp120-targeting proteins against laboratory-adapted HIV-1 virions in the absence (alone) or presence (in mixture) of gp41-targeting fusion inhibitor T20, T2635 or SFT.
| Combined with | 2Dm2m | 4Dm2m | ||||
|---|---|---|---|---|---|---|
| EC50 (nM) | Enhancement (fold) | EC50 (nM) | Enhancement (fold) | |||
| Alone | In mixture | Alone | In mixture | |||
| HIV-1IIIB (B, X4) | ||||||
| T20 | 0.99 | 0.23 | 4.3 | 0.39 | 0.06 | 6.5 |
| T2635 | 0.99 | 0.21 | 4.7 | 0.39 | 0.10 | 3.9 |
| SFT | 0.99 | 0.61 | 1.6 | 0.39 | 0.15 | 2.6 |
| HIV-1Bal (B, R5) | ||||||
| T20 | 1.29 | 0.24 | 5.4 | 0.27 | 0.11 | 2.5 |
| T2635 | 1.29 | 0.34 | 3.8 | 0.27 | 0.11 | 2.5 |
| SFT | 1.29 | 0.93 | 1.4 | 0.27 | 0.17 | 1.6 |
Data are representative of testing in triplicate (mean).