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. 2017 Jun 21;6(6):e59. doi: 10.1038/emi.2017.46

Table 2. Enhancement of the viral inactivation activity of the gp120-targeting proteins against laboratory-adapted HIV-1 virions in the absence (alone) or presence (in mixture) of gp41-targeting fusion inhibitor T20, T2635 or SFT.

Combined with 2Dm2m 4Dm2m
  EC50 (nM) Enhancement (fold) EC50 (nM) Enhancement (fold)
  Alone In mixture   Alone In mixture  
HIV-1IIIB (B, X4)
 T20 0.99 0.23 4.3 0.39 0.06 6.5
 T2635 0.99 0.21 4.7 0.39 0.10 3.9
 SFT 0.99 0.61 1.6 0.39 0.15 2.6
 
HIV-1Bal (B, R5)
 T20 1.29 0.24 5.4 0.27 0.11 2.5
 T2635 1.29 0.34 3.8 0.27 0.11 2.5
 SFT 1.29 0.93 1.4 0.27 0.17 1.6

Data are representative of testing in triplicate (mean).