Table 5. Enhancement of the inactivation activity of the gp120-targeting proteins against released virions from reactivated HIV-1 latent cells in the absence (alone) or presence (in mixture) of the gp41-targeting fusion inhibitor T20, T2635 or SFT.
| Combined with | 2Dm2m | 4Dm2m | ||||
|---|---|---|---|---|---|---|
| EC50 (nM) | Enhancement (fold) | EC50 (nM) | Enhancement (fold) | |||
| Alone | In mixture | Alone | In mixture | |||
| Released HIV-1 virions from reactivated HIV-1 latent cells | ||||||
| T20 | 1.58 | 0.49 | 3.2 | 0.66 | 0.11 | 6.0 |
| T2635 | 1.58 | 0.35 | 4.5 | 0.66 | 0.14 | 4.7 |
| SFT | 1.58 | 0.27 | 5.9 | 0.66 | 0.15 | 4.4 |
Data are representative of testing in triplicate (mean).