Fig. 1.

Regulators for Blimp-1 expression in a CD4⁺ T cells and b CD8⁺ T cells. Bach2, BTB and CNC homology 2; BATF, Basic leucine zipper transcription factor; Blimp-1, B lymphocyte-induced maturation protein-1; Egr-2, Early growth response gene 2; IL, Interleukin; IRF4, Interferon regulatory factor 4; KLF2, Kruppel-like factor 2; MHC II, Major histocompatibility complex class II; Prdm1, Positive regulatory domain 1; SOCS, Suppressor of cytokine signaling; STAT, Signal transducers and activators of transcription; TCR, T cell receptor. The solid line indicates direct action by activation of expression of the Prdm1 gene. The dashed line indicates regulations that require further investigation for underlying mechanisms