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. 2017 Jul 20;18:26. doi: 10.1186/s12860-017-0141-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 11 — Cladosporol A induces autophagy in human breast cancer (MCF-7 cells) (a). The autophagic vacuoles were observed under fluorescence microscope (40×) with MDC staining. The treatment of Cladosporol A and BEZ235 (positive control group) induced concentration-dependent formation of autophagic vacuoles in MCF-7 cells after 24 h. b Detection of autophagy with LC3b antibody using confocal microscopy. Immunocytochemical staining was conducted using anti-LC3b antibody and Alexa Flour-555-labelled secondary antibody. Nuclei were stained with DAPI. c Detection of autophagy by western blot analysis after Cladosporol A treatment in concentration dependent manner