FIG 8.

Passive transfer of immune serum fractions provides protective immunity against challenge with a lethal dose of WT B. mallei. (A) Experimental timeline and details. Naive serum was used as a control. (B) Kaplan-Meier survival curves. (C) Survival data during the acute and chronic phases of infection. (D, E, and F) Tissues were collected from mice that survived challenge, homogenized, diluted, and spread on agar plates to determine bacterial loads. The symbols show data for individual animals; the horizontal lines represent the mean total CFU for each group. The experiments were performed on 2 separate occasions (each time with freshly generated immune serum), and the graphs and table show cumulative results.