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Classification of BCL-2 family members. BCL-2 family members are grouped by their ability to inhibit or activate apoptosis. Shared, conserved BCL-2 homology (BH) domains and transmembrane (TM) regions are depicted. *Indicates recent evidence for BH3-only proteins that might also act as activator BH3-only pro-apoptotic proteins. Darkened circles indicate where there is evidence to support an alternative function for the BCL-2 family member
