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. 2017 Jun 23;24(8):1411–1421. doi: 10.1038/cdd.2017.64

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Copyright © 2017 The Author(s)

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Non-apoptotic role of caspases in dendritic arborization neuron remodelling. (a) Overview of Drosophila white pre-pupae (grey) with abdominal dendritic arborization (da) sensory neurons in superficial position on dorsal body wall aspect (green). (b) Da sensory neurons undergo remodelling during early metamorphosis. Pruning starts with initial thinning of branches, followed by severing at 6 h after puparium formation (APF), and is completed with the clearance fragments of the severed branches by 18 h APF. (c) The apoptotic machinery involved in the pruning of da neurons includes Dark (dApaf1), the fly caspaseDronc, DIAP1 and its regulator UbcD1. The question marks represent the current unknowns in the pathway. Ca²⁺, calcium ions; IBP, IAP-binding motif proteins; IK2, IκB kinase