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. 2017 Apr 10;6(4):e313. doi: 10.1038/oncsis.2017.13

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Copyright © 2017 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Clinical relevance of MCT-1 and its relationship with YY1, EGFR, MnSOD, CD31, CD163 and α-SMA in human lung cancer. (a) MCT-1 mRNA levels in lung cancer tissue (n=124) and normal lung tissue (n=13) were studied with the TissueScan arrays. The MCT-1 mRNA level in each tumor sample was normalized to the β-actin mRNA level and then calibrated to the average MCT-1 mRNA level in normal lung tissue. X² tests were used to evaluate the significance of MCT-1 overexpression at different tumor stages compared with the normal tissue. (b) MCT-1 mRNA levels were assessed in different tumor types, in lymph node metastasis (N⩾1) and in distant metastasis (M=1) using X² tests. (c) The correlation between MCT-1 expression levels and overall survival and recurrence-free survival (n=83) were analyzed using the Okayama dataset in the ONCOMINE database. (d) The overall survival of patients with an EGFR mutation associated with MCT-1 expression levels was analyzed in the Okayama dataset (n=43). (e) Pearson coefficient correlation defines the linkage between MCT-1 overexpression and YY1 (n=104). (f) The Phi coefficient shows the relationship of MCT-1 with YY1, EGFR, MnSOD and p53 in lung cancer patients (n=124). (g) Pearson coefficient correlation reveals the association between MCT-1 with CD31, CD163 and α-SMA in the lung cancers at stage III/IV (n=46) and at stage I/II (n=78). (h) Pearson coefficient correlation indicates the association between MCT-1 and CD31, CD163 and α-SMA in different types and stages of lung cancer in the ONCOMINE database (Bild, n=26; Weiss, n=217; Okayama, n=207).