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. 2017 Apr 3;6(4):e310. doi: 10.1038/oncsis.2017.14

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Copyright © 2017 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Overview of Wnt signaling regulators contributing to TNBC progression and their targeted therapies. Canonical and non-canonical Wnt pathways are activated through Fzd, LRP and ROR receptors. Blue arrows indicate suppression/inhibition of Wnt regulators and pathways (with a net result of downregulation of Wnt target gene transcription, indicated by yellow cross); red arrows indicate activation of Wnt regulators and pathways.