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. 2017 Apr 17;6(4):e317. doi: 10.1038/oncsis.2017.22

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Copyright © 2017 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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HBV integration with the neurotrimin (NTM) gene in HepaRG cells after 1-h exposure to NL02.C inoculum. (a) Schematic presentation of integration of HBx sequence (continuous lines) with NTM (shaded boxes) detected in eight separate clones (1–8). All clones displayed the same four-bp overlapping homolgous virus–host junction. Locations of the junction in Ch11q25 and in relation to the HBx sequence are shown. (b) Sequencing electropherograms depict in detail the nucleotides forming the OHJ. HBV and NTM sequences are marked by continuous and dashed lines, respectively. Enh-II, HBV enhancer II; DR1, direct repeat 1.