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. 2017 Apr 17;6(4):e317. doi: 10.1038/oncsis.2017.22

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Copyright © 2017 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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HBV integration with transposon LINE2 (L2) at 3 and 7 days post infection of HepaRG cells with NL01.A. (a) Integration of HBx (continuous lines) with LINE2 (shaded boxes) detected in four clones (1–4) obtained after 3 d.p.i. and in five clones (1–5) acquired at 7 d.p.i. (1–5). Different lengths of the LINE2 sequences identified, details on the HBV and LINE2 nucleotides forming the 11-bp homologous junction, except a singular nucleotide mismatch (T versus G), and location of the junction in relation to the HBx sequence and Ch11q13.4 are presented. (b) Electropherograms showing details on the contributions of HBV (continuous line) and LINE2 (dashed line) nucleotides to formation of the OHJ.