Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The cyclo-oxygenase dependent mechanism of action of aspirin. Aspirin treatment causes the post-translational modification of cyclo-oxygenase (Cox) proteins by acetylating serine residues (Cox-1Ser530 and Cox-2Ser516) on either Cox-1 & Cox-2 enzymes. This prevents arachidonic acid from accessing the catalytic site on the Cox enzymes. As a result there is reduced formation of the precursor for all prostaglandins (PGs) and therefore lower levels of prostaglandin E2 (PGE2).
