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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Antiviral Res. 2017 Apr 25;143:205–217. doi: 10.1016/j.antiviral.2017.04.012

Figure 3. Effects of the compounds on HBV DNA elongation.

Figure 3

Isolated HBV capsids were incubated with radiolabeled dNTPs and compounds at 4X their EC50s to measure DNA elongation by the encapsidated viral reverse transcriptase in an EPR reactions. Nucleic acids were harvested following the EPR reaction, resolved by electrophoresis, and detected by autoradiography.