Table 1.
Baseline Patient Characteristics, Stratified by PCOS vs MetS Status (N = 38)
| Characteristic | PCOS (n = 20) | MetS (n = 18) | P Value |
|---|---|---|---|
| Physical characteristics | |||
| Age, mean (SD), y | 37 (6) | 40 (6) | .06 |
| Body mass index, mean (SD), kg/m2 | 34.6 (5.1) | 33.7 (5.2) | .57 |
| Body fat, mean (SD), % | 39.0 (6.8) | 37.4 (6.2) | .44 |
| Race/ethnicity, No. (%) | .44 | ||
| White | 8 (40) | 5 (28) | |
| Black | 7 (35) | 10 (55) | |
| Hispanic | 5 (30) | 3 (17) | |
| Glucose metabolism, mean (SD) | |||
| Fasting glucose, mg/dL | 97 (6) | 95 (12) | .54 |
| Fasting insulin, μIU/mL | 11.1 (6.9) | 8.6 (8.5) | .08 |
| SI, min−1 × (μU/mL)−1 × 10−4 | 1.9 (1.0) | 3.0 (1.2) | .02 |
| AIRg, min × (μU/mL) | 701.6 (539.5) | 764.5 (388.6) | .68 |
| Disposition indexa | 1135.1 (643.4) | 2146.9 (1388) | .01 |
| Sg, min−1 × 100 | 1.7 (0.5) | 1.9 (0.98) | .36 |
| HOMA-IR | 2.8 (1.5) | 2.2 (2.7) | .45 |
| Sex steroid hormones, mean (SD) | |||
| Total testosterone, ng/dL | 45.6 (23.3) | 32.1 (15.3) | .04 |
| Free testosterone, ng/dL | 8.9 (6.4) | 5.6 (4.2) | .10 |
| Estradiol, pg/mL | 107.4 (70) | 118.4 (78) | .64 |
| Sex hormone-binding globulin, mcg/mL | 28.4 (15.6) | 35.4 (17.7) | .21 |
| Lipids, mean (SD), mg/dL | |||
| Total cholesterol | 191 (26) | 175 (39) | .15 |
| Low-density lipoprotein cholesterol | 120 (22) | 103 (30) | .05 |
| High-density lipoprotein cholesterol | 50 (8) | 51 (12) | .73 |
| Triglycerides | 105 (45) | 110 (53) | .78 |
Abbreviations: AIRg, acute insulin response to glucose; HOMA-IR, homeostasis model of insulin resistance; MetS, metabolic syndrome; PCOS, polycystic ovary syndrome; Sg, glucose effectiveness; SI, insulin sensitivity index.
a
Disposition index = SI × AIRg