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. Author manuscript; available in PMC: 2017 Jul 21.
Published in final edited form as: Mol Biosyst. 2015 Dec;11(12):3332–3346. doi: 10.1039/c5mb00488h

Fig. 2.

Fig. 2

Global sensitivity analysis reveals that TNFα is highly sensitive to TGFβ and IL-10. Total sensitivity indices (ST) were computed for each parameter and data are shown for all parameters with ST > 0.2. The temporal profile of the LPS-induced TNFα response, for saturating stimulus (LPS = 1000), is shown above the sensitivity index heatmap. Sensitivity indices were computed at times corresponding to the simulated waveform. All identified parameters involve one of the following cytokines: IL-1β, TGFβ, IL-10, or IL-6.