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. Author manuscript; available in PMC: 2018 Jul 15.
Published in final edited form as: J Immunol. 2017 Jun 7;199(2):806–815. doi: 10.4049/jimmunol.1700231

Figure 5. LLP2A avidity is driven by macrophages and T cells.

Figure 5

Granulomas from monkeys 182-14 (stars) and 183-14 (circles) were selected based on their (A) similar masses, and (B) significantly different CPM/gram values for additional analysis. (C) Cell numbers per granuloma cross section, n=3 granulomas/animal/group. *p<0.05. (B) Linear regression of cell numbers per cross section and CPM/granuloma suggest a strong relationship between macrophages (P<0.0001, r2=0.9834) and T cells (P<0.0006, r2=0.9328), but lower correlation between neutrophil (P<0.0001, r2=0.8875) and B cell (P<0.347, r2=0.5359) numbers and CPM. (C) Immunohistochemistry on low CPM (top) and high CPM (bottom) granulomas from monkey 183-14 show colocalization of integrin subunits in macrophage- and lymphocyte-rich granuloma regions. Scale bar represents 200 μm.