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Inhibition of insulin secretion by calcium channel blocker protects βTC3 cells from hypoxia-induced cell death. (a) Expression of cleaved caspase-3 in RGS2-overexpressing (RGS2) or control (Ds-Red CTR) cells treated with vehicle or calcium channel blocker, nifedipine, at 5 or 10 μM, and exposed to hypoxia for 4 or 8 h. (b) LDH activity in RGS2-overexpressing or control cells treated with vehicle or nifedipine and exposed to hypoxia for 24 h. *P<0.05, ANOVA test
