Figure 2.

Impact of AMD3100 and CCX771 on PMN infiltration into the lungs and alveolar thickness identified by immunohistochemistry. Neutrophils were stained with a specific marker and appear brown in histology (rat anti-mouse neutrophil, clone 7/4) (original magnification, × 63). AMD3100 is the specific inhibitor of CXCXR4; CCX771 inhibits CXCR7. All conditions were investigated in wild type (left column) and A_2B−/− animals (right column) (a). Images are representatives of n=4 experiments. Alveolar septae of the different conditions were measured in wild type (b) and A_2B−/− animals (c). Data are presented as mean ±S.D.; n≥8; *P<0.05 versus control; ^#P<0.05 versus LPS-treated