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. 2017 May 25;8(5):e2832. doi: 10.1038/cddis.2016.482

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Microvascular permeability was attenuated by CXCR4- and CXCR7-inhibitors. Six hours after LPS-inhalation, the capillary leakage was assessed by Evans blue extravasation and the influence of CXCR4-antagonism (AMD3100) (a) (respectively CXCR7-antagonism (CCX771) (b)) in wild-type and A_2B−/− animals (c, d) investigated. Data are presented as mean ±S.D.; n≥6; *P<0.05 versus control; ^#P<0.05 versus LPS-treated