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. 2017 May 25;8(5):e2832. doi: 10.1038/cddis.2016.482

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Combined inhibition of CXCR4 and CXCR7. The effect of simultaneous CXCR4- and CXCR7-antagonism was investigated in terms of PMN migration (IV=intravascular; IS=interstitial; BAL=bronchoalveolar lavage) (a), chemokine release (b) and microvascular permeability (c). There was no additive anti-inflammatory effect concerning PMN migration into the lung, but in terms of stabilizing the capillary leakage. Data are presented as mean ±S.D.; n≥6; *P<0.05 versus control; ^#P<0.05 versus LPS-treated; °P<0.05 versus single treatment of AMD3100 or CCX771