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. 2017 May 18;8(5):e2805. doi: 10.1038/cddis.2017.167

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Senescent polyploid hepatocytes are rejuvenated accompanied by ploidy converyor. In the aged liver, senescent polyploid hepatocytes reenter cell cycles after transplantation. These proliferating tetraploid or octoploid hepatocytes can generate mononucleated diploid and tetraploid hepatocytes, as well as binucleated tetraploidy with triploar or double mitosis. Accompanied with senescent hepatocytes reversal, the percentage of octoploid hepatocytes decreases while the percentage of diploid hepatocytes increases. The p16^ink4α and p53-p21 pathway regulating hepatocyte senescence may be a mechanism of polyploidization during aging