. 2017 May 18;8(5):e2805. doi: 10.1038/cddis.2017.167

Table 1. Genes contribute to polyploidy.

Gene symbol	Gene function	Genetic modification	Effect on liver polyploidization	References
E2f7/8	Cell cycle transcription factor	Deletion	Impair polyploidization	^{16, 24}
Ccne1	Cell cycle, G1/S transition	Deletion	Impair polyploidization	²⁵
E2f1/2/3	Cell cycle transcription factor	Deletion	Promote polyploidization	^{23, 24}
Trp53	Cell cycle factor, tumor supressor	Deletion	Promote polyploidization	^{26, 27}
p21	Cell cycle factor	Deletion	Promote polyploidization	²⁶
Rb	Cell cycle, mitosis	Deletion	Promote polyploidization	^{26, 28}
Cdk1	Cell cycle, mitosis	Deletion	Promote polyploidization	²⁹
Ccne2	Cell cycle, G1/S transition	Deletion	Promote polyploidization	²⁵
Skp2	Cell cycle	Deletion	Promote polyploidization	³⁰
Ssu72	Cell cycle	Deletion	Promote polyploidization	³¹
ERCC1	DNA repair	Deletion	Promote polyploidization	¹⁵
Survivin	Cell cycle, mitosis	Deletion	Promote polyploidization	^{32, 33}
miR-122	Proliferation	Overexprssion	Promote polyploidization	³⁴