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. 2017 May 11;8(5):e2779. doi: 10.1038/cddis.2017.192

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The in vivo accumulation of MDSCs was dependent on glycolysis. (a) Counts of CD11b⁺ cells in the blood of PBS-treated (ctrl) or 2-DG-treated normal (N) and 4T1-tumor-bearing (TB) mice at indicated time points after tumor inoculation. Arrow indicated the time point starting 2-DG treatment (n=3 per group). (b) Absolute numbers of CD11b⁺ cells in the indicated tissues of the mice in (a) at the fourth week after tumor inoculation (n=3 per group). (c) Size of tumor in the PBS-treated (ctrl) and 2-DG-treated tumor-bearing mice measured at the indicated time points (n=6–7 per group). (d) Immunohistochemical staining for detection and (e) quantification of Gr-1⁺ cells in the tumor and the liver of the PBS-treated (ctrl) and 2-DG-treated tumor-bearing mice at week 4 after tumor inoculation. Arrowheads indicated Gr-1⁺ cells (n=3 per group). Scale bars, 100 μm. All the data are representative of two independent experiments. ND, not done; ns, not significant. *P<0.05, **P<0.01 and ***P<0.001 (unpaired Student’s t-test). (a–c and e) Error bars, S.D.