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. 2017 May 11;8(5):e2781. doi: 10.1038/cddis.2017.196

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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CHCHD4 deficit confers protection against HI brain injury. (a) The photomicrographs (left) show representative MAP2 staining obtained 72 h after HI at the dorsal hippocampus and the striatum levels. The graph (right) shows the total tissue loss 72 h after HI (n=42 for Wt and n=41 for Het). (b) The bar graphs show the total pathological score and the pathological scores in the cortex (Cx), hippocampus (Hip), striatum (Str), and thalamus (Tha) in Wt and Het mice at 72 h after HI. (c) The microphotographs show representative MAP2 staining at 4 weeks after HI from the dorsal hippocampus and the striatum levels. The graph shows the tissue loss at 4 weeks after HI (n=10 for Wt and n=21 for Het). *P<0.05, **P<0.01, ***P<0.001