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. 2017 May 11;8(5):e2781. doi: 10.1038/cddis.2017.196

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Transcription of Keap1–Nrf2 pathway-related genes. (a) Nrf2, Keap1, Gclc, and Ho1 mRNA levels were quantified by qRT-PCR in P9 normal brain tissue as well as at 6 and 24 h after HI in Wt and Het mice (n=6 per group). No significant changes were observed between the genotypes. (b) Glutathione reductase (GLU) activity in the mitochondrial fraction was decreased at 6 h after HI compared with controls, and there was no significant difference between the genotypes under physiological conditions or after HI insult. *P<0.05, **P<0.01, ***P<0.001