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. 2017 May 11;8(5):e2782. doi: 10.1038/cddis.2017.197

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The majority of dysregulated genes in the APL progenitors are refractory to the corrective effect of ATRA or ATO. (a) Heatmap showing the dysregulated genes in the c-Kit⁺ APL progenitors compared with normal MPs (P<0.05, fold change ≥1.5). (b) Overlap analyses of ATRA/ ATO-refractory dysregulated genes with PML/RARα target genes. (c) Overlap analyses of ATRA/ATO-responsive dysregulated genes with PML/RARα target genes. (d) Heatmap showing the ATRA /ATO-refractory downregulated signal transducers and transcription factors