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. 2017 May 11;8(5):e2782. doi: 10.1038/cddis.2017.197

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Irf8 increases with the spontaneous monocytic differentiation of the APL progenitors. (a) Flow cytometry assay showing the differential expression of c-Kit, CD11b and AA4.1 in APL cells. (b) Measurement of the leukomogenic potential by inoculating serially diluted leukemia subsets into non-irradiated recipients. The observation time was ≥120 days. (c) Giemsa staining and microscopic inspection of sorted c-Kit⁺CD11b⁻ AA4.1⁺⁺ cells, c-Kit⁺CD11b⁺⁺ cells and c-Kit⁻CD11b⁺⁺ cells in the mouse APL model. (d) The mRNA levels of monocytic and granulocytic maturation-related genes in the APL progenitors and c-Kit⁻CD11b⁺⁺ mature cells in the mouse APL model as measured by RT-PCR assay. All data in this figure are presented as the mean±S.D., *P <0.05, **P<0.01