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. 2017 May 11;8(5):e2787. doi: 10.1038/cddis.2017.198

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Mad1 knockout inhibits cell death in the epithelium during T3-induced metamorphosis. (a) Cross-sections of the intestine of premetamorphic stage 54 tadpoles treated with 5 nM T3 for 0, 2 or 3 days were stained for apoptosis by TUNEL. Note that apoptosis in the epithelium peaked after 2 days of T3 treatment and that there were more intestinal epithelial cells in wild-type animals strongly stained by TUNEL compared with the ones in Mad1 ^(−/−) tadpoles. The dotted lines depict the epithelium–mesenchyme boundary. Scale bar, 50 μm. (b) Quantitative analysis of apoptosis by counting TUNEL-positive areas in the epithelium and normalized by the total cellular area in epithelium determined by Hoechst staining