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. 2017 May 18;8(5):e2801. doi: 10.1038/cddis.2017.208

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Chondrogenic effects of NGF on BMSCs in vivo. (a and b) Intraoperative photographs showed the location and size of the defect. (c) Macroscopic appearance of cartilage defect healing in the three groups at week 12 after surgery. (d) International Cartilage Repair Society macroscopic scores for all samples from the three groups at 4, 8 and 12 weeks after surgery. (e) Biomechanical testing. (f) Histological scores for the samples from the three groups at 4, 8 and 12 weeks after surgery, according to the scale described by Wakitani. (g) Masson’s trichrome staining were performed on cartilage sections. The values are means±S.D., n=10 joints; bars with different letters are significantly different from each other at P<0.05. (Original low magnification × 40 (scale bar, 500 μm); original high magnification × 200 (scale bar, 100 μm))