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. 2017 May 18;8(5):e2808. doi: 10.1038/cddis.2017.219

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Caspase-1 induces serum deprivation-induced apoptosis by increasing caspase-7 activation. Cells were transfected with C-miR, miR-101, control siRNA (siCtrl) or ASC siRNA (siASC), followed by treatment with Ac-YVAD-cho in serum-free media for 24 h (caspase assay) or 30 h (cell viability). (a−d) Caspase activity was determined in cell lysates by colorimetric assay. (e) Caspases-3/7 activation was determined by Western blot analysis. (f) Cell viability was evaluated by MTT assay. *P<0.05 and **P<0.01 versus cells transfected with C-miR or siCtrl in serum-free media