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Suppressive effects of betulin on LPS-induced endotoxin shock are Nrf2 dependent in mice. (a) Effect of betulin on the survival rate of wt or Nrf2−/−mice. Mice were treated with betulin (12 mg/kg) and LPS (40 mg/kg) as described in the Material and Methods (n=10); the survival rates are presented as survival curves. (b–d), Effect of betulin on the genes and protein expression in the lung tissue of mice. P*≤0.05, P**≤0.01 versus the LPS group; NS, no significant difference
