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. 2017 May 4;8(5):e2762. doi: 10.1038/cddis.2017.77

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Hyper-sialylation associated with ovarian cancer drives the specificity of SNA. (a) Binding of FITC-SNA to the surface of SKOV3 and IOSE-364 was seen through confocal imaging. Scale bar =10 μm (b) Immunohistochemical analysis showing binding of FITC-SNA (green, shown by arrow marks) to ovarian tissue sections. The nuclei were stained with DAPI. Bar=100 μm. (c) Surface binding of SNA was quantitated by flow cytometry in SKOV3 cells. (d) Quantitation of cellular viability was performed using MTT reagent in SKOV3 and WST-1 reagent in IOSE-364 cell lines. (e) BrdU proliferation assay was performed in SKOV3 and IOSE-364 cell lines with different doses of SNA as indicated