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. 2017 May 4;8(5):e2762. doi: 10.1038/cddis.2017.77

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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SNA exposure results in mitochondrial dysfunction. (a) SKOV3 cells stained with MitoTracker Red CMXROS were imaged for mitochondrial structure by confocal microscope. Scale bar represents 10 μm. (b-c) Graphs showing the mitochondrial length and perimeter of SKOV3 cells after indicated time period of SNA exposure. (d) Membrane potential of OAW-42 and IOSE-364 cells stained with JC-1 dye were measured by flow cytometry. (e) ROS production in OAW-42 and SKOV3 cells stained with Mitosox was analyzed by flow cytometry. (f) Western blot depicting cytosolic release of cytochrome-c in OAW-42, IOSE-364 cell lines after 24 h of SNA treatment with GAPDH as loading control. (g) Expression of cytochrome-c after 0, 4 and 8 h of SNA treatment in SKOV3 cells with GAPDH as loading control