Figure 5.

Quantification of the properties of the mIPSCs and mEPSCs. A, The interevent interval, amplitude and decay time of both mIPSCs and mEPSCs recorded in each cell are plotted for saline-transfected controls treated with DT (saline + DT, blue), virus-transfected controls treated with saline (DTR + saline, green) and interneuron-ablated mice transfected with virus and treated with DT (DTR + DT, red). Symbols indicate data from individual cells, and bars indicate the group averages. Data are plotted for the time point of days 6-8 after DT treatment. At this time, CA1 pyramidal cells from the experimental mice had a specific deficit in the frequency of mIPSCs (asterisks, p < 0.01, ANOVA; Tables 1, 2) but not the amplitude or decay time, consistent with the loss of inhibitory synapses. B, The >10-fold shift in interevent interval of mIPSCs can also be seen as a large shift in the cumulative probability plot for the DTR + DT compared to controls.