Biomarkers: executive summary
1.	The use of high-sensitivity cardiac troponin (hs-cTn) is recommended.
2.	The recommended algorithm is the 0–3 h type, using specifically validated hs-cTn.
3.	Whilst troponin is the diagnostic standard for AMI, it must be remembered that levels can be high in conditions other than ACS and an isolated increase does not allow the diagnosis of AMI, given that troponin is considered only to be a marker of myocardial damage.
4.	Stable values or inconsistent variations of troponin in the absence of dynamic variations in its plasma concentration (rise/fall with generation of a kinetic curve) do not constitute a marker of ACS.
5.	Practical cooperation with the blood analysis laboratory is essential, as also is knowledge of the diagnostic method (assay) utilized.
6.	Severe kidney failure causes cTn to increase (more so cTn-T than cTn-I). A higher cut-off value based on estimated glomerular filtration rate (eGFR) levels is needed for a more accurate diagnosis of AMI–NSTEMI in patients suffering from end-stage kidney failure.39